Publications   BioModels   Simulation Status   Simulation Tasks   (not logged in sign in)



Name
Model BioModel "SH2 biosensor", Application "Application0"
Ownerjmhaugh
Solver"Combined Stiff Solver (IDA/CVODE)"
num jobs6
check statuscheck status
check jobscheck jobs
datametadata
Overrides [keSH2 = 0.01 ] [EGF = 10 ] [SH2_init_uM =  100 300 1,000 ] [koff =  1 100 ]


Parameters

name default value override unit description context
_K_GHK_ 0
type
expression
cardinality
values
_N_pmol_ 602,214,179,000
type
expression
cardinality
values
EGF_init_uM 1
type
expression
cardinality
values
[uM] initial concentration for EGF App(Application0) / Species(EGF)
EGFR_init_uM 100
type
expression
cardinality
values
[uM] initial concentration for EGFR App(Application0) / Species(EGFR)
EGFRSH2_init_uM 0
type
expression
cardinality
values
[uM] initial concentration for EGFRSH2 App(Application0) / Species(EGFRSH2)
iEGFR_init_uM 0
type
expression
cardinality
values
[uM] initial concentration for iEGFR App(Application0) / Species(iEGFR)
iEGFRSH2_init_uM 0
type
expression
cardinality
values
[uM] initial concentration for iEGFRSH2 App(Application0) / Species(iEGFRSH2)
K_millivolts_per_volt 1,000
type
expression
cardinality
values
kdeg 0.05
type
expression
cardinality
values
[s-1] user defined Global
ke 0.1
type
expression
cardinality
values
[s-1] user defined Model / Reaction(r2)
keSH2 0.1
type
expression
cardinality
values
[s-1] user defined Model / Reaction(r7)
kf 0.1
type
expression
cardinality
values
[s-1.uM-1] user defined Global
KMOLE 0.002
type
expression
cardinality
values
koff 1
type
expression
cardinality
values
[s-1] user defined Global
kon 0.1
type
expression
cardinality
values
[s-1.uM-1] user defined Global
kr 0.1
type
expression
cardinality
values
[s-1] user defined Global
kt 0.01
type
expression
cardinality
values
[s-1] user defined Model / Reaction(r1)
pEGFR_init_uM 0
type
expression
cardinality
values
[uM] initial concentration for pEGFR App(Application0) / Species(pEGFR)
pEGFRSH2_init_uM 0
type
expression
cardinality
values
[uM] initial concentration for pEGFRSH2 App(Application0) / Species(pEGFRSH2)
SH2_init_uM 0
type
expression
cardinality
values
[uM] initial concentration for SH2 App(Application0) / Species(SH2)
Size_c0 50,000
type
expression
cardinality
values
[um3] size App(Application0) / Compartment(c0)
Vsyn 1
type
expression
cardinality
values
[uM.s-1] user defined Model / Reaction(r1)
JSON response
{"key":"94782974","branchId":"94782975","name":"Complex internalizes at turnover rate; vary koff and [SH2] 1","ownerName":"jmhaugh","ownerKey":"13213103","mathKey":"94782596","solverName":"Combined Stiff Solver (IDA/CVODE)","scanCount":6,"bioModelLink":{"bioModelKey":"94891280","bioModelBranchId":"94740608","bioModelName":"SH2 biosensor","simContextKey":"94782653","simContextBranchId":"94740676","simContextName":"Application0"},"overrides":[{"name":"keSH2","type":"Single","values":[0.01],"cardinality":1},{"name":"EGF","type":"Single","values":[10.0],"cardinality":1},{"name":"SH2_init_uM","type":"List","values":[100.0,300.0,1000.0],"cardinality":3},{"name":"koff","type":"List","values":[1.0,100.0],"cardinality":2}],"parameters":[{"name":"_K_GHK_","defaultValue":1.0E-9},{"name":"_N_pmol_","defaultValue":6.02214179E11},{"name":"EGF_init_uM","defaultValue":1.0,"modelSymbolContext":"App(Application0) / Species(EGF)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for EGF","modelSymbolUnit":"uM"},{"name":"EGFR_init_uM","defaultValue":100.0,"modelSymbolContext":"App(Application0) / Species(EGFR)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for EGFR","modelSymbolUnit":"uM"},{"name":"EGFRSH2_init_uM","defaultValue":0.0,"modelSymbolContext":"App(Application0) / Species(EGFRSH2)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for EGFRSH2","modelSymbolUnit":"uM"},{"name":"iEGFR_init_uM","defaultValue":0.0,"modelSymbolContext":"App(Application0) / Species(iEGFR)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for iEGFR","modelSymbolUnit":"uM"},{"name":"iEGFRSH2_init_uM","defaultValue":0.0,"modelSymbolContext":"App(Application0) / Species(iEGFRSH2)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for iEGFRSH2","modelSymbolUnit":"uM"},{"name":"K_millivolts_per_volt","defaultValue":1000.0},{"name":"kdeg","defaultValue":0.05,"modelSymbolContext":"Global","modelSymbolType":"ModelParameter","modelSymbolName":"kdeg","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1"},{"name":"ke","defaultValue":0.1,"modelSymbolContext":"Model / Reaction(r2)","modelSymbolType":"KineticsParameter","modelSymbolName":"ke","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1"},{"name":"keSH2","defaultValue":0.1,"modelSymbolContext":"Model / Reaction(r7)","modelSymbolType":"KineticsParameter","modelSymbolName":"keSH2","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1"},{"name":"kf","defaultValue":0.1,"modelSymbolContext":"Global","modelSymbolType":"ModelParameter","modelSymbolName":"kf","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1.uM-1"},{"name":"KMOLE","defaultValue":0.001660538783162726},{"name":"koff","defaultValue":1.0,"modelSymbolContext":"Global","modelSymbolType":"ModelParameter","modelSymbolName":"koff","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1"},{"name":"kon","defaultValue":0.1,"modelSymbolContext":"Global","modelSymbolType":"ModelParameter","modelSymbolName":"kon","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1.uM-1"},{"name":"kr","defaultValue":0.1,"modelSymbolContext":"Global","modelSymbolType":"ModelParameter","modelSymbolName":"kr","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1"},{"name":"kt","defaultValue":0.01,"modelSymbolContext":"Model / Reaction(r1)","modelSymbolType":"KineticsParameter","modelSymbolName":"kt","modelSymbolDesc":"user defined","modelSymbolUnit":"s-1"},{"name":"pEGFR_init_uM","defaultValue":0.0,"modelSymbolContext":"App(Application0) / Species(pEGFR)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for pEGFR","modelSymbolUnit":"uM"},{"name":"pEGFRSH2_init_uM","defaultValue":0.0,"modelSymbolContext":"App(Application0) / Species(pEGFRSH2)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for pEGFRSH2","modelSymbolUnit":"uM"},{"name":"SH2_init_uM","defaultValue":0.0,"modelSymbolContext":"App(Application0) / Species(SH2)","modelSymbolType":"SpeciesContextSpecParameter","modelSymbolName":"initConc","modelSymbolDesc":"initial concentration for SH2","modelSymbolUnit":"uM"},{"name":"Size_c0","defaultValue":50000.0,"modelSymbolContext":"App(Application0) / Compartment(c0)","modelSymbolType":"StructureMappingParameter","modelSymbolName":"Size","modelSymbolDesc":"size","modelSymbolUnit":"um3"},{"name":"Vsyn","defaultValue":1.0,"modelSymbolContext":"Model / Reaction(r1)","modelSymbolType":"KineticsParameter","modelSymbolName":"Vsyn","modelSymbolDesc":"user defined","modelSymbolUnit":"uM.s-1"}]}